Microfragmented fat
Microfragmented fat is produced from belly or thigh fat that has been aspirated using a plastic surgery syringe and then passed through a mechanical device which separates off the useful cells for transplantation.
This separation frees the portion called the 'stromal vascular fraction' (SVF) where pluripotent cells migrate off the small blood vessels where they usually reside. They move to damaged areas and facilitate healing.
However, a 2025 publication suggests that there is "no statistically significant differences for both the clinical outcomes and pain scores between microfragmented adipose tissue and other orthobiologics for the treatment of knee osteoarthritis."