If one looks at the microscopic structure of cartilage one will see that it is composed primarily of a slippery white 'matrix' containing few cells and strengthened by the incorporation of randomly arranged elastin fibres.

articular cartilage of knee joint

The matrix has a high water content, a fairly high collagen content (a structural protein) and a percentage of something called proteoglycans (including chondroitin and keratin sulphate) which are responsible for attracting the water into the cartilage and maintaining its compressive strength.

Within the matrix are a relatively few cartilage cells ('chondrocytes') suspended, often quite apart from one another, within small 'bubbles' called lacunae.

Where the cartilage layer joins onto the bone beneath it is a region known as the 'tidemark'.

 

Tidemark

If the cartilage is lacerated, cuting through the tidemark and into the sub-chondral bone then some healing can occur, although the cartilage that forms is 'fibrocartilage' rather than true joint (or 'articular') cartilage. This can occur because stem cells from the bone marrow can migrate into the blood clot that forms and these cells can mature into fibrocartilage. This type of cartilage is weaker than the original cartilage, but better than nothing.

grade 4 cartilage damage

If there is a split but it does not go through the tidemark, there is no healing, and gradually the surface will become friable, and fibrillated, and the cartilage will wear away down to the bone, as you can see in this photograph which has been taken during keyhole surgery (courtesy Prof Adrian Wilson).

 

Osteoarthritis

Cartilage breakdown is the first stage of osteoarthritis. Initially the process may be painless, but pain will become a feature once the underlying bone becomes exposed.

 

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